Drug Standards
Selleck Chemical LLC Mifepristone 50mg 84371-65-3 RU486, C-1073
Mifepristone (RU486, C-1073) is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. Mifepristone promotes cell autophagy and apoptosis, decreases Bcl-2 level and increases Beclin1 level, accompanied by weakened interaction between Bcl-2 and Beclin1. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Ivermectin 50mg 70288-86-7 MK933
Ivermectin (MK-933, IVM) is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug. Ivermectin (MK-933, IVM) is a specific positive allosteric effector of P2X4 and ?7 nicotinic acetylcholine receptors (nAChRs). Ivermectin has potent antiviral activity towards both HIV-1 and dengue virus. Ivermectin induces autophagy through the AKT/mTOR signaling pathway and mitophagy. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Caspofungin Acetate 5mg 179463-17-3 MK-0991
Caspofungin acetate (MK-0991) is an lipopeptide antifungal ?-1,3-glucan synthase inhibitor. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Capecitabine 50mg 154361-50-9 RO 09-1978
Capecitabine (RO 09-1978) is a tumor-selective fluoropyrimidine carbamate, which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU. Capecitabine treatment of HCT-15 cells causes condensation of DNA and induces apoptosis. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC CB-5083 5mg 1542705-92-9
CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor with IC50 of 11 nM. Phase 1. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Ponesimod 5mg 854107-55-4 ACT-128800
Ponesimod (ACT-128800) is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator with EC50 of 5.7 nM. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Melphalan 100mg 148-82-3 Alkeran, Sarcolysin, L-PAM
Melphalan (Alkeran, Sarcolysin, L-PAM) is a phenylalanine derivative of nitrogen mustard with antineoplastic activity. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC 3-deazaneplanocin A (DZNeP) HCl 1mg 120964-45-6 NSC 617989 HCl
3-deazaneplanocin A HCl (DZNeP, NSC 617989), an analog of adenosine, is a competitive inhibitor of S-adenosylhomocysteine hydrolase with Ki of 50 pM in a cell-free assay. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Stavudine (d4T) 100mg 3056-17-5 BMY-27857, Sanilvudine, NSC 163661
Stavudine (d4T, BMY-27857, Sanilvudine, NSC 163661) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Sigma Aldrich Fine Chemicals Biosciences Orphenadrine hydrochloride European Pharmacopoeia (EP) Reference Standard | 341-69-5 | MFCD00012480 |
Orphenadrine hydrochloride European Pharmacopoeia (EP) Reference Standard | Mol Wt: 305.84 | 341-69-5 | MFCD00012480 |
Medchemexpress LLC Tivantinib (ARQ 197) | 905854-02-6 | 99.6% | 369.42 | 5 MG
Tivantinib is a highly selective c-Met tyrosine kinase inhibitor with a Ki of 355 nM. It is a low-molecular-weight compound and the first orally available selective inhibitor of c-Met. Tivantinib selectively inhibits c-Met activity in cell-free and cell-based assays, causing dose-dependent loss of proliferative capacity or caspase-dependent apoptosis in c-Met-expressing cancer cell lines.
- Highly selective c-Met tyrosine kinase inhibitor
- Ki of 355 nM
- Selectively inhibits c-Met activity in cell-free and cell-based assays
- First orally available selective inhibitor of c-Met
- Inhibits constitutive c-Met phosphorylation in HT29 and MKN-45 cells, and HGF-induced c-Met phosphorylation in MDA-MB-231 and NCI-H441 cells with an IC50 of 100 to 300 nM
- Strongly inhibits c-Met phosphorylation in human colon xenograft tumors (HT29)
Selleck Chemical LLC Drospirenone 25mg 67392-87-4 ZK 3059
Drospirenone (ZK 3059) is a synthetic progestin that is an analog to spironolactone. *For Research & Development use only. Product is not intended for drug, household, or human consumption.